It's been almost a year since Cyrus Smith and Antigone Smith earned their places as Journeymen at Ashtown, home of an ancient order of explorers that has long guarded the world's secrets and treasures. While their studies go well, Cy and Tigs are not well liked since losing the Dragon's Tooth to the nefarious Dr. Phoenix. The Tooth is the only object in the world capable of killing the long-lived transmortals, and Phoenix has been tracking them down one by one, and murdering them.
The surviving transmortals, led by legendary warrior Gilgamesh of Uruk, descend on Ashtown in force, demanding justice. Cyrus and Antigone find themselves on the run in a desperate search to locate Phoenix and regain the Tooth. In the process, they uncover an evil even more dangerous than Phoenix, one that has been waiting for centuries to emerge.